Trouble reading MODBUS register using Python

I am trying to use Python (PyCharm) to read a register on a modbus device. I have confirmed the COM port, Baud rate and other communication settings and I can use the devices application to read the value (it is a water level logger). I am getting no response from the instrument.

Register is readable in mbpoll using -

mbpoll -B -m RTU  -t 4:float -a 1 -b 19200 -r 46 -c 2 /dev/ttyUSB0

(Address different as running on Pi not PC)

And MBPOLL -

My code is as follows -

import minimalmodbus
import serial

instrument = minimalmodbus.Instrument('COM5', 1)  # port name, slave address (in decimal)
instrument.serial.port = 'COM5'                     # this is the serial port name
instrument.serial.baudrate = 19200         # Baud
instrument.serial.bytesize = 8
instrument.serial.parity   = serial.PARITY_EVEN
instrument.serial.stopbits = 1
instrument.serial.timeout  = 3          # seconds
instrument.address = 1                         # this is the slave address number
instrument.mode = minimalmodbus.MODE_RTU   # rtu or ascii mode
instrument.clear_buffers_before_each_transaction = True

temperature = instrument.read_float(registeraddress=40046, functioncode=3, number_of_registers=2, byteorder=0)  # Registernumber, number of decimals
print(temperature)
 

Error Received -

Any help appreciated!

EDIT: Link to device manual - https://in-situ.com/en/pub/media/support/documents/Modbus_Manual.pdf Device is a Level Troll 400 Connected to PC via manufactures cable

EDIT 2: I have tried to incorporate minimal modbus structure but to no avail.

EDIT 3: I am able to read a register using Modbus Poll. Register is 40046, so I understand this to be register 45 of the holding registers? How do I translate this to minimalmodbus?

EDIT 4: I am not married to minimal modbus - I am happy to use any tool to get this done

EDIT 5: I have also tried depth = instrument.read_long(x, x) with different values

from Trouble reading MODBUS register using Python