Error: Handshake inactivity timeout in Node.js MYSQL module

I'm using node-mysql and most of the queries. Working. some queries not working. I tried every version of Node (from 0.5...) until (5.6.0), I also tried (4.0) and (4.1), Nothing helps.

I tried to change maually, and didn't work. I tried to change the sequence file to: this._idleTimeout = -1; and didn't help.

I read the issues and GitHub, and nothing helped.

I can try to fix it by myself, but I need more information. Where is the timeout, why? when? what is this type of message? Where is the timeout came from?

MYSQL_ERROR     { [Error: Handshake inactivity timeout]  
code: 'PROTOCOL_SEQUENCE_TIMEOUT',   fatal: true,   
timeout: 10000 }  

from Error: Handshake inactivity timeout in Node.js MYSQL module